The England Lions slumped to their third straight loss after going down to Victoria by eight wickets in Melbourne on Wednesday.
Scott Boland claimed 4-29 as the Lions were bowled out for 173 in the 49th over after being sent in to bat at the MCG.
Rob Quiney blasted a superb 76 off 87 balls in reply as Victoria ran out comfortable winners with 75 deliveries to spare.
The result capped an underwhelming week for the Lions, who were beaten by the Bushrangers and a Victorian XI in their opening two tour matches.
The Lions were under pressure early on following the dismissals of openers Varun Chopra and James Vince for single figures.
Vince (three) was caught behind off Jayde Herrick (1-39), while Chopra was out in the same fashion to Marcus Stoinis (1-7) for just four off 27 balls.
The tourists fell to 3-18 in the ninth over following the loss of Ben Foakes (one), before James Taylor and Gary Ballance steadied the ship.
Taylor added 31 off 61, while Ballance hit four fours on his way to 57 off 96 until his dismissal in the 41st over.
The Lions lost their last four wickets for just 11 runs as Boland and Fawad Ahmed (2-21) tore through the bottom order.
In reply, Quiney hit two sixes and six fours to put Victoria in a commanding position, with fellow opener Handscomb adding 32 off 52.
Michael Hill (45 not out) and Cameron White (14 not out) then combined for the winning runs in the 38th over.
The Lions will now turn their attention to a five-match series with Australia A which gets underway in Hobart on Saturday.
First Posted 13 February, 2013 6:11PM AEST