Australian captain Michael Clarke took five wickets as the West Indies lower order collapsed to a 75-run defeat in the third and final Test in Roseau.
Australia had already reclaimed the Frank Worrell Trophy with a draw in the second Test but went on to claim an outright 2-0 win in the series after the hosts resumed day five at 5-173 and were bowled out for 294 in pursuit of 370.
The dismissal of the West Indies' Shivnarine Chanderpaul (69) on the last ball of the fourth day had put Australia in charge on Thursday.
The hosts looked in a commanding position in their second innings with around 10 overs of play remaining before two late wickets, including that of Darren Bravo (45), swung momentum Australia's way.
With only one specialist batsman - Narsingh Deonarine - remaining, Clarke (5-86) took little time to add to his three-wicket haul from day four with his wicket in his fourth over.
After a review, Deonarine was adjudged to have connected amid a huge puff of dust as he punched the ball straight back to Clarke, who took the catch.
With Deonarine gone for 13 the hosts were pegged back to 6-180 and already into their tail.
Wicketkeeper Carlton Baugh (12) was the next to go some seven overs later after attempting another big hit that fell to Ricky Ponting at midwicket, off the bowling of Nathan Lyon.
Captain Darren Sammy continued to resist Clarke and Lyon's spin attack and smashed the Australian captain for two boundaries and a six the over after Baugh's wicket.
Lyon soon bagged his second after a thin edge from Kemar Roach (two) followed through to Clarke at slip as he took a sensational grounding catch.
The West Indies were nine down when Ravi Rampaul provided Clarke with his fifth wicket the next over.
The seamer tried to loft Clarke down the ground but didn't quite get onto it and David Warner was made to wait for an eternity before taking the catch at mid-on.
That wicket presented part-timer Clarke with his second five-wicket haul in his career.
Darren Sammy (61) posted a late defiant half-century as he and 10-wicket hero Shane Shillingford put on 49 runs for the last wicket, but it was not enough in the end.
Sammy's attempted sweep off Lyon was top-edged straight to Ben Hilfenhaus at short fine leg, who took the catch to conclude the series and a tiring period of Test cricket for Australia.
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of Cricket Australia
First Posted 28 April, 2012 7:43AM AEDT