Pace pair James Anderson and Mark Wood have been ruled out of England's tour of Bangladesh following a recurrence of their recent injuries.
Anderson, who missed the first Test of England's recent home series against Pakistan due to a stress fracture to his right shoulder, has been plagued by the same injury and has been advised to rest ahead of their tour of India.
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Durham seamer Wood has had a recurrence of the left ankle problem that ruled him out of much of the northern summer.
In their stead, Nottinghamshire quick Jake Ball has been added to the Test squad, while Steve Finn from Middlesex joins the ODI squad, with selectors set to consider a further replacement for the Test squad at a later date.
Ball, 25, debuted for the Test side against Pakistan at Lord's in July, after making an impression at the beginning of the County Championship season with good pace and the ability to swing the ball.
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Finn played in Middlesex's title-winning county match last week and has 65 ODIs to his name, though he hasn't played for England in the format since September last year.
Anderson last week expressed concern over England's schedule in the upcoming period, with the side set to play seven Tests in two months on the subcontinent.
"It's a tough one because as a player, if you're fit, you want to play, simple as that," he said. "No matter what the format, you're desperate to play.
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"But there may well come a time when it will get managed. At 34 I probably have to manage myself, or be managed, quite well.
"You want, if possible, to play every Test but India is going to be five back-to-back and that's a huge ask for any bowler."
England now look set to begin the red-ball leg of the Bangladesh tour without their most prolific batsman and captain, as well as their star bowler Anderson. Test skipper Alastair Cook, who will travel to Bangladesh a week ahead of the rest of the Test squad, will then return to the United Kingdom for the birth of his second child.
Cook will miss the two warm-up matches but is expected to be back in time for the first Test in Chittagong, starting on October 20.